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Table 3 LASSO, Univariate and Multivariate analysis of factors predicting CCC and Intra-procedural Factors

From: Factors predicting conversion from colon capsule endoscopy to conventional optical endoscopy—findings from the CESCAIL study

Factors associated with CCE to further endoscopy procedure conversion

Factors

(n = 247)

LASSO

coefficient

Univariate analysis

Multivariate analysis with LASSO variables

Odd ratio

95% CI

p-value

Odd ratio

95% CI

p-value

Log(f-Hb)

0.0081

1.47

1.20–1.81

 < 0.001***

1.48

1.18–1.86

 < 0.001***

Smoking

− 0.2925

1.5

1.05–2.17

0.034*

1.44

1.01–2.11

0.047*

Factors associated with Incomplete Capsule Excretion

Factors

(n = 385)

LASSO

coefficient

Univariate analysis

Multivariate analysis

Odd ratio

95% CI

p-value

Odd ratio

95% CI

p-value

Age

-

0.99

0.97–1.00

0.010**

0.99

0.96–1.01

0.209

Sex—Male

-

2.13

1.36–3.38

0.001**

2.22

1.10–4.58

0.024*

Creatinine

-

1.01

1.00–1.03

0.035*

1.00

0.98–1.02

0.796

Factors associated with Bowel Cleansing

Factors

(n = 338)

LASSO

coefficient

Univariate analysis

Multivariate analysis

Odd ratio

95% CI

p-value

Odd ratio

95% CI

p-value

Age

-

0.99

0.97–1.00

0.020*

0.99

0.97–1.01

0.272

Sex—Male

-

1.46

1.05–2.04

0.023*

1.72

0.93–3.22

0.084

Diabetes

-

0.54

0.31–0.93

0.028*

0.40

0.18–0.87

0.022*

Factors associated with Significant Pathology (Polyp > = 10 mm or > = 5 polyps)

Factors

(n = 221)

Linear regression Polyp Size

Linear regression Polyp Number

Regression coefficient

95% CI

p-value

Regression coefficient

95% CI

p-value

Alcohol

0.27

− 0.58 to 1.11

0.628

0.79

0.41 to 1.16

0.023*

Smoking

0.88

0.13 to 1.64

0.301

0.76

0.42 to 1.09

0.025*

Psychological conditions

0.57

− 0.37 to 1.51

0.632

1.05

0.63 to 1.47

0.013*

Antidepressant (Yes)

2.16

1.18 to 3.13

0.028*

− 0.47

− 0.90 to − 0.04

0.278

Beta Blocker

− 4.55

− 6.22 to − 2.88

0.008**

− 0.72

− 1.46 to 0.02

0.339

Haemoglobin

0.02

− 0.01 to 0.04

0.460

− 0.02

− 0.04 to − 0.01

0.046*

  1. CI Confident Interval, f-Hb Faecal haemoglobin, FIT Faecal immunochemical test, LASSO Least absolute shrinkage and selection operator