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Table 3 Summary and comparison of the immunohistochemical features and biological behaviors of small intestinal stromal tumors at different sites

From: Unraveling the site-specific features in small intestinal stromal tumors: a retrospective study

Variables

Duodenum#

Jejunum#

Ileum#

P value

P value Between groups

Diameter of tumor

3.8 (2.6, 5.4)

5.5 (3.1, 8.0)

7.5 (5.2, 10.0)

<0.001*

Duodenum vs. Jejunum <0.001*

Jejunum vs. Ileum 0.005*

Duodenum vs. Ileum<0.001*

c-KIT (CD117)

Positive: 111 (100%)

Negative: 2 (2%)

Partial positive: 2 (2%)

Positive: 106 (96%)

Negative: 2 (2%)

Partially positive: 2 (2%)

Positive: 84 (96%)

0.205

/

DOG-1

Positive: 110 (100%)

Negative: 1 (1%)

Positive: 105 (99%)

Negative: 3 (3%)

Partially positive: 5 (6%)

Positive: 79 (91%)

<0.001*

Duodenum vs. Jejunum 0.491

Jejunum vs. Ileum 0.008*

Duodenum vs. Ileum 0.001*

CD34

Negative: 15 (13%)

Partially positive: 19 (17%)

Vascular positive: 19 (17%)

Positive: 58 (52%)

Negative: 13 (12%)

Partially positive: 23 (21%)

Vascular positive: 21 (19%)

Positive: 52 (48%)

Negative: 13 (15%)

Partially positive: 13 (15%)

Vascular positive: 17 (19%)

Positive: 45 (51%)

0.933

/

Ki-67

<5%: 68 (62%)

≥ 5%: 41 (38%)

<5%: 57 (52%)

≥ 5%: 53 (48%)

<5%: 36 (41%)

≥ 5%: 51 (59%)

0.013*

Duodenum vs. Jejunum 0.134

Jejunum vs. Ileum 0.154

Duodenum vs. Ileum 0.004*

SDHB

Negative: 6 (9%)

Partially positive: 4 (6%)

Positive: 59 (86%)

Negative: 1 (2%)

Partially positive: 2 (3%)

Positive: 57 (95%)

Negative: 2 (5%)

Partially positive: 1 (3%)

Positive: 34 (92%)

0.406

/

SMA

Negative: 38 (34%)

Partially positive: 26 (23%)

Vascular positive: 1 (1%)

Positive: 46 (41%)

Negative: 38 (35%)

Partially positive: 21 (19%)

Vascular positive: 1 (1%)

Positive: 50 (46%)

Negative: 23 (27%)

Partially positive: 21 (26%)

Vascular positive: 3 (4%)

Positive: 36 (43%)

0.616

/

S-100

Negative: 94 (85%)

Partially positive: 13 (12%)

Neural positive: 1 (1%)

Positive: 3 (3%)

Negative: 96 (87%)

Partially positive: 10 (9%)

Positive: 4 (4%)

Negative: 70 (81%)

Partially positive: 11 (13%)

Positive: 5 (6%)

0.749

/

Desmin

Negative: 106 (97%)

Partially positive: 2 (2%)

Positive: 1 (1%)

Negative: 101 (95%)

Partially positive: 4 (4%)

Positive: 1 (1%)

Negative: 81 (95%)

Partially positive: 3 (4%)

Positive: 1 (1%)

0.933

/

Mitotic count /50HPF

2.0 (1.0, 4.5)

3.0 (1.5, 7.5)

5.0 (2.0, 10.0)

0.002*

Duodenum vs. Jejunum 0.163

Jejunum vs. Ileum 0.316

Duodenum vs. Ileum 0.002*

T category

T1: 11 (9.8%)

T2: 71 (63.4%)

T3: 28 (25.0%)

T4: 2 (1.8%)

T1: 9 (8.0%)

T2: 41 (36.3%)

T3: 45 (39.8%)

T4: 18 (15.9%)

T1: 3 (3.3%)

T2: 19 (20.7%)

T3: 49 (53.3%)

T4: 21 (22.8%)

<0.001*

Duodenum vs. Jejunum<0.001*

Jejunum vs. Ileum 0.024

Duodenum vs. Ileum<0.001*

N category

N0: 111 (99.1%)

N1: 1 (0.9%)

N0: 113 (100.0%)

N1: 0 (0%)

N0: 92 (100%)

N1: 0 (0%)

0.644

/

M category

M0: 109 (97.3%)

M1: 3 (2.7%)

M0: 105 (92.9%)

M1: 8 (7.1%)

M0: 81 (88.0%)

M1: 11 (12.0%)

0.034*

Duodenum vs. Jejunum 0.126

Jejunum vs. Ileum 0.231

Duodenum vs. Ileum 0.009*

Risk category

Very low risk: 9 (8.0%)

Low risk: 59 (52.7%)

Intermediate risk: 9 (8.0%)

High risk: 35 (31.3%)

Very low risk: 7 (6.2%)

Low risk: 40 (35.4%)

Intermediate risk: 4 (3.5%)

High risk: 62 (54.9%)

Very low risk: 1 (1.1%)

Low risk: 12 (13.0%)

Intermediate risk: 5 (5.4%)

High risk: 74 (80.4%)

<0.001*

Duodenum vs. Jejunum 0.004*

Jejunum vs. Ileum<0.001*

Duodenum vs. Ileum<0.001*

  1. T, primary tumor; N, Regional lymph nodes; M, distant metastasis; HPF, high power fields
  2. # Continuous variables conforming to the normal distribution were presented as the mean ± standard deviation (\(\:\stackrel{-}{x}\)±s), while continuous variables not conforming to the normal distribution were illustrated as median (25th percentile, 75th percentile). Categorical variables were represented as total number (percentages of the corresponding research population)
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BMC Gastroenterology

ISSN: 1471-230X

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